WebDec 20, 2024 · A class of histamine receptors discriminated by their pharmacology and mode of action. Most histamine H1 receptors operate through the inositol … WebHistaprodifen, methylhistaprodifen, and dimethylhistaprodifen are potent H1-receptor agonists in the pithed and in the anaesthetized rat B. Malinowska, J. Piszcz, E. Schlicker, …
(PDF) Molecular characterization of specific H1-receptor
WebAll drugs, except dimethylhistaprodifen, were activators of G-proteins. Their order of potency was suprahistaprodifen > histamine > histaprodifen > methylhistaprodifen. Their effect on G-protein activation was abolished by the addition of the H1-receptor antagonist triprolidine (10 μM), which given alone did not activate G-proteins. WebWe have shown previously that histaprodifen and its Nalpha-substituted analogues methylhistaprodifen and dimethylhistaprodifen are highly potent H1-receptor agonists in vivo. The aim of the present study was to examine the influence of four newly synthesized histaprodifen analogues, 3-fluoro-methylhistaprodifen (1), Nalpha ... field gate rising hinges
Dimethylhistaprodifen C22H27N3 ChemSpider
WebWe have shown previously that histaprodifen and its Nalpha-substituted analogues methylhistaprodifen and dimethylhistaprodifen are highly potent H1-receptor agonists in vivo. The aim of the present study was to examine the influence of four newly synthesized histaprodifen analogues, 3-fluoro-methylhistaprodifen (1), Nalpha … WebSelective H1-receptor agonists with a potency exceeding that of histamine have become available only recently; the most potent are methylhistaprodifen and … Webdimethylhistaprodifen [Nα-methyl- and Nα,Nα-dimethyl-2-(3,3-diphenylpropyl)histamine, respectively] with 3.4- and 2.4-fold higher potencies than histamine in vitro (in the guinea … fieldgate square balga