WebA higher score on a composite index of homologous recombination deficiency (HRD), indicating genomic instability, correlated with improved progression-free survival (PFS) and overall survival (OS) in patients with ovarian cancer who have received platinum-containing chemotherapy, according to results presented at the 2016 Society of … Webbetween genomic instability caused by genomic stress and anti-tumor immunity, and proposed the idea of predicting ICB therapy response through the state of genomic stress [16]. However, the research of genomic instability- derived risk index (GIRI) in ccRCC has not been reported.
ESMO Congress OncologyPRO
WebMay 6, 2024 · Construction of genomic instability-derived risk index (GIRI) for patients with ccRCC in the training set. (a) Kaplan-Meier survival plot of the high-risk GIRI and the low-risk GIRI. (b) Comparison of time-dependent receiver operating characteristic curves among the GIRI, age, gender, tumor grade, and clinical stage. WebMar 13, 2024 · Chromosome instability describes the increased probability of acquiring chromosomal aberrations due to defects in processes such as DNA repair, replication or chromosome segregation. Related... athira patel instagram
Genome Instability - an overview ScienceDirect Topics
Genome instability (also genetic instability or genomic instability) refers to a high frequency of mutations within the genome of a cellular lineage. These mutations can include changes in nucleic acid sequences, chromosomal rearrangements or aneuploidy. Genome instability does occur in bacteria. In multicellular organisms genome instability is central to carcinogenesis, and in humans it is also a factor in some neurodegenerative diseases such as amyotrophic lateral sclerosis or th… WebBackground: Lower-grade gliomas (LGGs) are a heterogeneous set of gliomas. One of the primary sources of glioma heterogeneity is genomic instability, a novel characteristic of cancer. It has been reported that long noncoding RNAs (lncRNAs) play an essential role in regulating genomic stability. However, the potential relationship between genomic … WebGenome-wide identification, classification and expression analysis of the JmjC domain-containing histone demethylase gene family in Moso bamboo ... In addition, analysis of the instability index showed that JmjC proteins were unstable (Instability index > … athira maritim indonesia