Gwas and obesity

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August undefined, 2024

WebGenome-wide association studies (GWAS) for BMI, waist-to-hip ratio, and other adiposity traits have identified more than 300 single-nucleotide … WebApr 7, 2024 · One plausible, but largely unexplored source of heterogeneity in obesity-associated CVD risk is the impact of body fat distribution (central versus overall obesity), …

GWAS for BMI: a treasure trove of fundamental insights …

WebJan 25, 2014 · The 39 included studies were reviewed in depth to find SNPs associated with to BMI, waist circumference, waist-hip ratio, fat percentage, fat mass or metabolic … WebBackground Lung function is a heritable complex phenotype with obesity being one of its important risk factors. However, knowledge of their shared genetic basis is limited. Most genome-wide association studies (GWASs) for lung function have been based on European populations, limiting the generalisability across populations. Large-scale lung function … bunny rabbit picture postcard prints

The genetics of obesity: from discovery to biology - Nature

WebJul 2, 2024 · Obesity is linked to many human diseases, including diabetes, cancer, and heart disease. There is thus great interest in understanding how genes predispose individuals to, or protect individuals from, obesity. ... WebJul 2, 2024 · In the genome era, genome-wide association study (GWAS) is a major and effective approach to discover genes and SNPs that contribute to complex diseases. To date, 46 obesity GWASs and 12 meta-analyses had reported 445 SNPs involved in 389 genes with a significant threshold P < 5×10 −8. The future challenge of obesity genetic … WebIn 2006, just before the first study that used GWAS for identification of BMI related variants was published, many researchers in the obesity field believed that we knew much about … bunny rabbit picture post

Genes in human obesity loci are causal obesity genes …

Genome-wide association studies of obesity and metabolic

WebThe discovery of FTO as the first obesity susceptibility gene. In 2007, within a time period of three months, two studies claimed the discovery of FTO as the first GWAS-identified obesity-susceptibility gene. 8-10 FTO was first discovered through a GWAS of type 2 diabetes in Europeans, comparing 1,924 cases and 2,938 controls. 8 A cluster of single … WebApr 7, 2024 · Conclusion: Our GWAS of obesity subclasses demonstrated unique genetic and functional properties between groups, supporting the contention that CVD risk may differ across obese individuals. We intend to replicate our novel association of OTX2 with BMI, waist-to-hip ratio, and waist circumference in people who rapidly gained weight in other ... halliday\u0027s functional grammarWebJan 29, 2024 · By the two sample MR approach using the MR-Base platform , this study aims to investigate the causal effects of obesity and T2D in COVID-19-associated hospitalization in European populations based on two large GWASs on obesity and T2D, including the GWAS on obesity harboring 263,407 individuals of European ancestry , … bunny rabbit pictures

"WebSep 7, 2024 · Author summary Human GWAS have identified hundreds of genetic variants associated with human obesity. The genes being regulated by these variants at the … " - Gwas and obesity

Gwas and obesity

Genome-wide association study of morbid obesity in Han Chinese

WebWe agree that GWAS for BMI is not perfect, but consider that the best route forward for additional discoveries will likely be to expand the search for common and rare variants … WebMar 23, 2024 · Here, we evaluated whether 32 genome-wide association study (GWAS)-identified variants for obesity were associated with the risk of MM in 4189 German subjects from the German Multiple Myeloma Group (GMMG) cohort (2121 MM cases and 2068 controls) and 1293 Spanish subjects (206 MM cases and 1087 controls).

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WebThe Effect of Obesity on the Pharmacokinetics of Pantoprazole in Children and Adolescents The Effect of Obesity on the Pharmacokinetics of ... (39 to less than 42 weeks gestation) … WebIf a variant responsible for a GWAS locus also affects gene expression, it is known that the relevant gene could be involved in the biological mechanism of disease pathogenesis. 32 …

WebDec 18, 2024 · As obesity is becoming pandemic, morbid obesity (MO), an extreme type of obesity, is an emerging issue worldwide. It is imperative to understand the factors … WebFeb 25, 2024 · Clinical characteristics of the 42,393 individuals included in the GWAS are shown in Table 1, and further details categorized by disease status are in Additional file 1: Tables S1–S3. The leading SNPs in association with CAD, IS, and CCD for each group are described in Table 2.The full lists of genome-wide significant (P-value < 5 × 10 –8) and …

WebDec 31, 2024 · GWAS identified variants associated with birth weight (BW), childhood obesity (CO) and childhood BMI (CBMI), and placenta is a critical organ for fetal development and postnatal health. We examined the role of placental transcriptome and eQTLs in mediating the genetic causes for BW, CO and CBMI, and applied integrative … WebSep 21, 2024 · The growing number of BMI GWAS loci and genes implicated through rare-variant association studies of common and syndromic forms of obesity, in conjunction …

WebAug 19, 2015 · Obesity affects more than 500 million people worldwide and contributes to type 2 diabetes, cardiovascular disorders, and cancer. 1 Obesity is the result of a positive energy balance, whereby ...

WebJan 24, 2024 · The obesity- and eBMD-associated TBX15 gene has highly tissue-specific expression unlike its neighbour, WARS2. TBX15 is highly and preferentially expressed in tissues or cell types relevant to the studied GWAS traits. It is associated with WHR adjBMI, WC adjBMI and BMI in many GWAS (Supplementary Table 1). Of all the obesity-trait … bunny rabbit postage stampsWebMay 1, 2024 · Both body mass index (BMI) obesity and MPDs have substantial heritability, ... We used GWAS summary statistics results for BMI, 38 SCZ, 11 BIP, 39 and MD. 40 The BMI data were obtained from GIANT and UK BioBank (n = 795 640). The MD data were generated by meta-analyzing the Psychiatric Genomics Consortium GWAS and the … bunny rabbit pictures to printWebJan 20, 2024 · Author summary Overweight and obese individuals are at risk for various medical conditions in Taiwan. Thus, we performed a genome-wide association study (GWAS) on four adiposity traits, … bunny rabbit pixel artWebFeb 11, 2024 · This GWAS identified 14 PCOS-associated variants reaching a P-threshold of 5×10 −8. From PCOS GWAS, we extracted IV obesity-PCOS associations and relevant information. We also downloaded the full set GWAS summary statistics of PCOS in which data from 23andMe were excluded (due to data availability) (Additional file 1: Table. S5). bunny rabbit pictures to colorWebAmong the general population, there is a category of individuals with an innate predisposition to obesity. In recent decades, the increase in the prevalence of obesity and related diseases worldwide indicates the need to study the etiological factors associated with its development. ... Most of the GWAS studies have been conducted in the ... bunny rabbit pillowsWebAug 1, 2024 · Genome-Wide Association Studies (GWAS) have been ongoing since 2007 to help associate specific genetic variations with certain diseases. Around 250 genes are … bunny rabbit print fabricWebJan 24, 2024 · Obesity-associated disorders are amongst the leading causes of morbidity and mortality worldwide. Most genome-wide association studies (GWAS) have focused on body mass index (BMI = weight in Kg divided by height squared (m 2)) and obesity, but to date no genetic association study testing thin and healthy individuals has been … bunny rabbit print out