Mitf hematopoiesis
Web4 aug. 2016 · Hematopoietic stem cells (HSCs) maintain quiescence by activating specific metabolic pathways, including glycolysis. We do not yet have a clear … Web3 apr. 2014 · By means of a prediction analysis method, MITF, P21 and P27 were regarded as potential regulators of the expression of HoxB4, a critical hematopoietic transcriptional factor . MITF was identified as a candidate for transcription factors mediating the activation of HOXB4 through HXRE-2.
Mitf hematopoiesis
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Web30 aug. 2024 · Bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs) sit atop a hierarchy that gives rise to all blood cells (Wang and Ema, 2016).They are largely quiescent or slow proliferating and consist of pluripotent long-term (LT) and short-term (ST) hematopoietic stem cells (HSCs), which differ in their ability to self-renew and support … Web6 nov. 2015 · Primary myelofibrosis (PMF) is a proliferative hematopoietic stem cell disorder associated in some cases with mutations in the JAK-STAT signal transduction pathway. Here the authors performed a detailed genetic analysis of blood and bone marrow samples and identified the gain of function of the polyamine oxidase PAOX and the loss …
WebThe results define MITF and PU.1 as nuclear effectors thatintegrateCSF-1/RANKLsignalsduringosteoclastdiffer- entiation to initiate expression of target genes, … Web27 dec. 2011 · DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in...
Web12 mrt. 2024 · Microphthalmia-associated transcription factor (Mitf) is broadly expressed and plays essential roles in the hematopoietic system. Here, we used Mitf -mutated … Web13 jan. 2024 · MiTF and haematopoiesis The haematopoietic system is a pyramidal organization with multipotent haematopoietic stem cells (HSCs) at the apex and mature blood cells at the bottom, with haematopoiesis being the process by which the naive …
Web27 dec. 2011 · A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient …
Web15 jun. 2000 · Members of the small Maf family of transcription factors play important roles in hematopoiesis. Using transgenic assays, we discovered a tissue-specific enhancer 3′ to the mafK gene. This enhancer directs mafK transcription in hematopoietic as well as in developing cardiac muscle cells, and was thus designated the h ematopoietic and c … c4 \u00265 zWeb12 mrt. 2024 · Microphthalmia-associated transcription factor (Mitf) is broadly expressed and plays essential roles in the hematopoietic system. Here, we used Mitf-mutated … c4 today\\u0027s programmesWeb13 jan. 2024 · The microphthalmia-associated transcription factor family (MiT family) consists of four transcription factors: MITF (microphthalmia-associated transcription factor or melanocyte-inducing... c4 \u0027slightWebMicropthalmia-associated transcription factor (MITF) ... and frameshift deletions and insertions are observed in cancers such as hematopoietic and lymphoid cancers, intestinal cancer, and lung cancer. MITF is altered in 1.10% of all cancers with colon adenocarcinoma, lung adenocarcinoma, ... c4 \\u0027tilWebUnlike Myc and Mycn, Mycl is dispensable for development into adulthood (16, 17).However, Mycl is known to retain transcriptional activity and to serve as a functional proto-oncogene in numerous cancer cell lines (3, 18, 19).Following a precise analysis of transcription factors expressed by dendritic cells (DCs), the first hematopoietic lineage that requires normal … c4 \u0027tWeb3 jun. 2010 · Hematopoiesis is a highly orchestrated multi-step process regulated by transcription factors that involves the proliferation, differentiation and maturation of a very small population of... c4 \u0027tilWebmitf敲除后对嗜碱性粒细胞和肥大细胞生成影响最大， STAT5 -/- 小鼠表现为pre-BMP和BaP数量锐减，外周血难以 检测到嗜碱性粒细胞、肥大细胞，相同 ... c4 \u0027ve