Splet20. mar. 2024 · Compared with the BLM+PBS treatment group, the level of TGF-β1 was significantly lower in the BLM+GSPE treatment group on day 21. Data are expressed as … SpletThese data demonstrate clear separations between PBS-, bleomycin- and bleomycin+pirfenidone-treated groups, and underscore the power of this approach. Metabolomics is the study of global endogenous metabolite profiles generated by specific cellular processes. The presented metabolomic analyses has the potential to enhance …
Targeting protease activated receptor-1 with P1pal-12 limits …
Spletfractions. A t-test between total protein abundance of PBS-treated lungs and lungs 14 days after bleomycin revealed 1,125 signifi-cantly regulated proteins (FDR < 5%; Table EV1). … Splet29. jun. 2015 · Bleomycin was instilled intranasally into wild-type or PAR-2–deficient mice in the presence/absence of a specific PAR-2 antagonist (P2pal-18S). ... Unless indicated … josh bean portland
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Splet25. avg. 2011 · Based on previous studies, the PAI-1 mutant proteins were injected at a dose of 100 μg in 100 μL of PBS every 12 hours until euthanasia. 28 Plasma and … Splet14. apr. 2024 · Transforming growth factor-β (TGF-β) has a strong impact on the pathogenesis of pulmonary fibrosis. Therefore, in this study, we investigated whether derrone promotes anti-fibrotic effects on TGF-β1-stimulated MRC-5 lung fibroblast cells and bleomycin-induced lung fibrosis. Long-term treatment with high concentrations … SpletIn our study, a bleomycin-challenged murine model was used to assess ZA’s anti-fibrotic efficacy. Bleomycin-induced fibrosis reproduces several phenotypic features of human IPF, including peripheral alveolar septal thickening, dysregulated cytokine production, and immune cell influx (Tashiro et al., 2024; Tanner and Single, 2024). how to landscape with native plants